In vitro evaluation of antiatherogenic potential of Origanum × paniculatum, Lippia alba, Clinopodium nepeta, and Eucalyptus globulus essential oils

CASTRO, MARÍA AGUSTINA; GIROTTI, JUAN ROBERTO; DUMRAUF, BÁRBARA; RODENAK-KLADNIEW, BORIS; ZARO, MARÍA JOSÉ; OTERO, CAMILA MARIEL; MONTERO-VILLEGAS, SANDRA; DE BRAVO, MARGARITA GARCÍA; VIÑA, SONIA ZULMA; CRESPO, ROSANA

Journal of Herbal Medicine

Elsevier

Lugar: Amsterdam; Año: 2023 vol. 42

2210-8033

ntroduction: Essential oils (EOs) are mixtures of secondary plant metabolism compounds with potential lipid-lowering activity and antioxidant properties. They may therefore be considered as add-on therapy for the prevention and treatment of cardiovascular diseases.Methods: EOs of Origanum × paniculatum (OpEO), Lippia alba (chemotype linalool) (LaLEO), Clinopodium nepeta (CnEO) and Eucalyptus globulus (EgEO), were evaluated on THP-1 foam cell macrophages as a cellular model of atherogenesis. Cell viability was determined by the MTT assay, lipid content by thin-layer chromatography, and Oil Red O staining. Antioxidant activity was evaluated by TBARS on low-density lipoprotein lipid peroxidation, and by ABTS•+, DPPH•, and FRAP assays. EOs were characterized by gas chromatography–mass spectrometry and a predictive multivariate data analysis was performed by partial least square regression (PLS) to identify the components related to antiatherogenic potential. Results: OpEO reduced foam cel